Low-grade serous ovarian cancer is serious

Let’s talk about LGSOC

Let’s talk about LGSOC

Low-grade serous ovarian cancer is a serious disease that can be seriously misunderstood.

Low-grade serous ovarian cancer (also known as LGSOC) is a rare type of cancer. It is distinct from the more common high-grade serous ovarian cancer (also known as HGSOC) and grows and spreads more slowly. LGSOC is likely to come back after initial treatment.

This site was created to be your go-to source for information about LGSOC. It includes a range of resources to help address a variety of needs specific to people with LGSOC.

Bookmark this site and come back often to stay up to date on LGSOC.

What is low-grade serous ovarian cancer?

Low-grade serous is a type of ovarian cancer that starts in the thin layer of tissue around the ovaries (also known as the epithelium).

Low-grade means that the cancer cells look a lot like normal cells. They also tend to grow and spread slowly.

Serous means that the cancer started in the serous membrane, which is part of the epithelium.

  • Many people with LGSOC are diagnosed in their 40s, but we know that doctors have treated people as young as 14 years old and as old as 79 years old
  • LGSOC is a serious disease that is likely to be diagnosed when it has already spread outside of the ovaries
  • 85% of people with LGSOC will have their cancer come back

What is low-grade serous ovarian cancer?

Low-grade serous is a type of ovarian cancer that starts in the thin layer of tissue around the ovaries (also known as the epithelium).

Low-grade means that the cancer cells look a lot like normal cells. They also tend to grow and spread slowly.

Serous means that the cancer started in the serous membrane, which is part of the epithelium.

Low-grade serous is a type of ovarian cancer that starts in the thin layer of tissue around the ovaries (also known as the epithelium).

Low-grade means that the cancer cells look a lot like normal cells. They also tend to grow and spread slowly.

Serous means that the cancer started in the serous membrane, which is part of the epithelium.

  • Many people with LGSOC are diagnosed in their 40s, but we know that doctors have treated people as young as 14 years old and as old as 79 years old
  • LGSOC is a serious disease that is likely to be diagnosed when it has already spread outside of the ovaries
  • 85% of people with LGSOC will have their cancer come back

How common is a diagnosis of low-grade serous ovarian cancer?

  • 5% to 10% of all serous ovarian cancers are LGSOC
  • Some of the symptoms of LGSOC are similar to other cancers and other diseases, like irritable bowel syndrome (IBS). This, combined with how rare the cancer is, may make LGSOC difficult to diagnose and not all doctors may have experience treating it.

How common is a diagnosis of low-grade serous ovarian cancer?

  • 5% to 10% of all serous ovarian cancers are LGSOC
  • Some of the symptoms of LGSOC are similar to other cancers and other diseases, like irritable bowel syndrome (IBS). This, combined with how rare the cancer is, may make LGSOC difficult to diagnose and not all doctors may have experience treating it.

What are the symptoms of low-grade serous ovarian cancer?

The symptoms of LGSOC are “SERIOUS”.

Stomach bloating
Eating less because you feel full
Repeated changes to bowel movements
Intense back and pelvic pain
Ongoing for up to 2 weeks
Urgent need to urinate
Stomach pain

Some of the symptoms of LGSOC are the same as other ovarian cancers and other diseases, like irritable bowel syndrome (IBS).*

*This list is not exhaustive, as these are not all of the symptoms of LGSOC. Discuss any/all symptoms that you feel may be related to LGSOC with your doctor.

How is low-grade serous ovarian cancer different from high-grade serous ovarian cancer?

Both LGSOC and HGSOC are likely to come back after treatment. Other than that, they are like night and day.

LGSOC

Uncommon
About 5% of serous ovarian cancers

Affects younger patients
Many people are diagnosed in their 40s but have been diagnosed as young as 14 years old

Normal-looking cells
 Cells look like non-cancer cells

Grows slowly
Cancerous cells grow slowly but persistently

Progresses slowly
Can start as benign (non-cancerous) tumors
before becoming cancerous and spreading

Does not respond well to chemotherapy
Resistant to chemotherapy, so other
treatments may be required

HGSOC

Very common
About 95% of serous ovarian cancers

Affects older patients
Most patients are over 50 years old

Abnormal-looking cells
 Cells look unstructured or underdeveloped

Grows quickly
Cancerous cells grow quickly

Progresses rapidly
Spreads quickly outside of ovaries

Responds well to chemotherapy

Responsive to chemotherapy, which can
slow/stop spread of cancer

Hear from low-grade serous ovarian cancer experts and patients

Learn more about LGSOC from doctors who treat it. Listen to patients discuss their experiences with diagnosis and treatment of LGSOC.

Hear from low-grade serous ovarian cancer experts and patients

Learn more about LGSOC from doctors who treat it. Listen to patients discuss their experiences with diagnosis and treatment of LGSOC.

Talk to your doctor about LGSOC

Talk to your doctor about LGSOC

1. About low grade serous ovarian cancer. Cure Our Ovarian Cancer. Updated August 17, 2019. Accessed February 23, 2023. https://cureourovariancancer.org/us/about/low-grade-serous-ovarian-cancer/

2. Behring S. Understanding low-grade serous ovarian cancer and its effects. Healthline. Updated June 8, 2022. Accessed February 23, 2023. https://www.healthline.com/health/ovarian-cancer/low-grade-ovarian-cancer

3. Cancer stat facts: ovarian cancer 2019. National Cancer Institute Surveillance, Epidemiology, and End Results Program. The Wayback Machine. Accessed February 23, 2023. http://web.archive.org/web/20190504121451/https://seer.cancer.gov/statfacts/html/ovary.html

4. Committee on the State of the Science in Ovarian Cancer Research; Board on Health Care Services; Institute of Medicine; National Academies of Sciences, Engineering, and Medicine. Ovarian Cancers: Evolving Paradigms in Research and Care. Washington (DC): National Academies Press (US); 2016. https://doi.org/10.17226/21841

5. Dao F, Schlappe BA, Tseng J, et al. Characteristics of 10-year survivors of high-grade serous ovarian carcinoma. Gynecol Oncol. 2016;141(2):260-263. https://doi.org/10.1016/j.ygyno.2016.03.010

6. Data on file. Verastem, Inc; 2022.

7. Dey P, Nakayama K, Razia S, et al. Development of low-grade serous ovarian carcinoma from benign ovarian serous cystadenoma cells. Cancers (Basel). 2022;14(6):1506. https://doi.org/10.3390/cancers14061506

8. Dictionary of cancer terms: serous membrane. National Cancer Institute. Accessed February 23, 2023. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/serous-membrane

9. Epithelial ovarian cancer. Cleveland Clinic. Reviewed January 3, 2022. Accessed February 23, 2023. https://my.clevelandclinic.org/health/diseases/22250-epithelial-ovarian-cancer

10. Gadducci A, Cosio S. Therapeutic approach to low-grade serous ovarian carcinoma: state of art and perspectives of clinical research. Cancers (Basel). 2020;12(5):1336. https://doi.org/10.3390/cancers12051336

11. Gershenson DM. The life and times of low-grade serous carcinoma of the ovary. Am Soc Clin Oncol Educ Book. 2013. https://doi.org/10.14694/EdBook_AM.2013.33.e195

12. Gershenson DM, Bodurka DC, Lu KH, et al. Impact of age and primary disease site on outcome in women with low-grade serous carcinoma of the ovary or peritoneum: results of a large single-institution registry of a rare tumor. J Clin Oncol. 2015;33(24):2675-2682. https://doi.org/10.1200/JCO.2015.61.0873

13. Gershenson DM, Sun CC, Lu KH, et al. Clinical behavior of stage II-IV low-grade serous carcinoma of the ovary. Obstet Gynecol. 2006;108(2):361-368. https://doi.org/10.1097/01.AOG.0000227787.24587.d1

14. Gockley A, Melamed A, Bregar AJ, et al. Outcomes of women with high-grade and low-grade advanced-stage serous epithelial ovarian cancer. Obstet Gynecol. 2017;129(3):439-447. https://doi.org/10.1097/AOG.0000000000001867

15. Grabowski JP, Harter P, Heitz F, et al. Operability and chemotherapy responsiveness in advanced low-grade serous ovarian cancer. An analysis of the AGO Study Group metadatabase. Gynecol Oncol. 2016;140(3):457-462. https://doi.org/10.1016/j.ygyno.2016.01.022

16. High-grade serous carcinoma. Ovarian Cancer Research Alliance. Published July 27, 2021. Accessed February 23, 2023. https://ocrahope.org/news/high-grade-serous-carcinoma/

17. Holschneider CH, Berek JS. Ovarian cancer: epidemiology, biology, and prognostic factors. Semin Surg Oncol. 2000;19(1):3-10. https://onlinelibrary.wiley.com/doi/10.1002/1098-2388(200007/08)19:1%3C3::AID-SSU2%3E3.0.CO;2-S

18. Lisio MA, Fu L, Goyeneche A, Gao Z-H, Telleria C. High-grade serous ovarian cancer: basic sciences, clinical and therapeutic standpoints. Int J Mol Sci. 2019;20(4):952. https://doi.org/10.3390/ijms20040952

19. Matsuo K, Machida H, Grubbs BH, Sood AK, Gershenson DM. Trends of low-grade serous ovarian carcinoma in the United States. J Gynecol Oncol. 2018;29(1):e15. https://doi.org/10.3802/jgo.2018.29.e15

20. NCCN Guidelines for Patients®: Ovarian Cancer, 2022. ©National Comprehensive Cancer Network, Inc. 2022. All rights reserved. Accessed February 23, 2023. https://www.nccn.org/patients/guidelines/content/PDF/ovarian-patient.pdf

21. Serous Carcinoma. ScienceDirect. Accessed February 23, 2023. https://www.sciencedirect.com/topics/medicine-and-dentistry/serous-carcinoma

22. Slomovitz B, Gourley C, Carey MS, et al. Low-grade serous ovarian cancer: state of the science. Gynecol Oncol. 2020;156(3):715-725. https://doi.org/10.1016/j.ygyno.2019.12.033

23. Tumor grade. National Cancer Institute. Updated August 1, 2022. Accessed February 23, 2023. https://www.cancer.gov/about-cancer/diagnosis-staging/diagnosis/tumor-grade

24. What are the symptoms of ovarian cancer? Cure Our Ovarian Cancer. Accessed February 23, 2023. https://cureourovariancancer.org/us/ovarian-cancer-symptoms/?gclid=EAIaIQobChMIrdHnx7Lb-gIVA_jICh1eFA_qEAAYASAAEgI8Q_D_BwE