A serious disease that can be seriously misunderstood
LGSOC is distinct and different from the more common high-grade serous ovarian cancer (HGSOC) and should be treated differently by your medical team. Get the facts about LGSOC.
Low-grade serous ovarian cancer symptoms are similar to other cancers and different diseases, like irritable bowel syndrome (IBS)—LGSOC may be overlooked and take a long time to diagnose.
Treatment options
The FDA has not yet approved a treatment specifically for LGSOC—that doesn’t mean that doctors don’t have options.
Clinical trials
Clinical trials going on right now may lead to breakthrough treatments for people with LGSOC.
Self-care
Living with LGSOC comes with a unique set of challenges, making it especially important to keep up with self-care.
Stay informed
Stay up to date on the latest information, news, and clinical trials.
References
Babaier A, Mal H, Alselwi W, Ghatage P. Low-grade serous carcinoma of the ovary: the current status. Diagnostics (Basel). 2022;12(2):458.
Gershenson DM. Low-grade serous carcinoma of the ovary or peritoneum. Ann Oncol. 2016;27(Suppl 1):i45-i49.
Slomovitz B, Gourley C, Carey MS, et al. Low-grade serous ovarian cancer: state of the science. Gynecol Oncol. 2020;156(3):715-725.
Harvard Health. Certain symptoms may be early signs of ovarian cancer. Accessed July 9, 2024. https://www.health.harvard.edu/cancer/certain-symptoms-may-be-early-signs-of-ovarian-cancer
Referenced with permission from the NCCN Guidelines for Patients® for Ovarian Cancer, 2023. © National Comprehensive Cancer Network, Inc. 2023. All rights reserved. Accessed July 18, 2024. To view the most recent and complete version of the NCCN Guidelines for Patients, go online to NCCN.org/patientguidelines
Data on file. Verastem, Inc.
Banerjee SN, Ring KL, Nieuwenhuysen EV, et al. Initial efficacy and safety results from ENGOT-ov60/GOG-3052/RAMP 201: a phase 2 study of avutometinib (VS-6766) ± defactinib in recurrent low-grade serous ovarian cancer (LGSOC). J Clin Oncol. 2023;41(suppl 16):5515. doi:10.1200/JCO.2023.41.16_suppl.5515
Grisham RN, Slomovitz BM, Andrews N, et al. Low-grade serous ovarian cancer: expert consensus report on the state of the science. Int J Gynecol Cancer. 2023;33(9):1331-1344.
Norton TR, Manne SL, Rubin S, et al. Prevalence and predictors of psychological distress among women with ovarian cancer. J Clin Oncol. 2004;22(5)919-926.
MD Anderson Cancer Center. Social & emotional impacts of cancer. Accessed July 9, 2024. https://www.mdanderson.org/patients-family/life-after-cancer/social-emotional-impacts.html
